Longitudinal Lipidomic Profile of Hypertension in American Indians: Findings From the Strong Heart Family Study-Reference-Cited by-同舟云学术

Longitudinal Lipidomic Profile of Hypertension in American Indians: Findings From the Strong Heart Family Study

Published:2023-08 Issue:8 Volume:80 Page:1771-1783
ISSN:0194-911X
Container-title:Hypertension
language:en
Short-container-title:Hypertension

Author:

Chen Mingjing¹^ORCID,Miao Guanhong¹^ORCID,Zhang Ying²,Umans Jason G.³⁴^ORCID,Lee Elisa T.²,Howard Barbara V.³⁴,Fiehn Oliver⁵,Zhao Jinying¹^ORCID

Affiliation:

1. Department of Epidemiology, Center for Genetic Epidemiology and Bioinformatics, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville (M.C., G.M., J.Z.).

2. Center for American Indian Health Research, Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center (Y.Z., E.T.L.).

3. MedStar Health Research Institute, Hyattsville, MD (J.G.U., B.V.H.).

4. Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (J.G.U., B.V.H.).

5. West Coast Metabolomics Center, University of California – Davis (O.F.).

Abstract

BACKGROUND: Dyslipidemia is an important risk factor for hypertension and cardiovascular disease. Standard lipid panel cannot reflect the complexity of blood lipidome. The associations of individual lipid species with hypertension remain to be determined in large-scale epidemiological studies, especially in a longitudinal setting. METHODS: Using liquid chromatography-mass spectrometry, we repeatedly measured 1542 lipid species in 3699 fasting plasma samples at 2 visits (1905 at baseline, 1794 at follow-up, ~5.5 years apart) from 1905 unique American Indians in the Strong Heart Family Study. We first identified baseline lipids associated with prevalent and incident hypertension, followed by replication of top hits in Europeans. We then conducted repeated measurement analysis to examine the associations of changes in lipid species with changes in systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Network analysis was performed to identify lipid networks associated with the risk of hypertension. RESULTS: Baseline levels of multiple lipid species, for example, glycerophospholipids, cholesterol esters, sphingomyelins, glycerolipids, and fatty acids, were significantly associated with both prevalent and incident hypertension in American Indians. Some lipids were confirmed in Europeans. Longitudinal changes in multiple lipid species, for example, acylcarnitines, phosphatidylcholines, fatty acids, and triacylglycerols, were significantly associated with changes in blood pressure measurements. Network analysis identified distinct lipidomic patterns associated with the risk of hypertension. CONCLUSIONS: Baseline plasma lipid species and their longitudinal changes are significantly associated with hypertension development in American Indians. Our findings shed light on the role of dyslipidemia in hypertension and may offer potential opportunities for risk stratification and early prediction of hypertension.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

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