SPRINT Revisited: Updated Results and Implications

Author:

Wright Jackson T.1ORCID,Whelton Paul K.2ORCID,Johnson Karen C.3,Snyder Joni K.4,Reboussin David M.5,Cushman William C.3ORCID,Williamson Jeff D.6,Pajewski Nicholas M.5ORCID,Cheung Alfred K.7,Lewis Cora E.8ORCID,Oparil Suzanne9ORCID,Rocco Michael V.10ORCID,Beddhu Srinivasan7,Fine Lawrence J.4,Cutler Jeffrey A.4,Ambrosius Walter T.5,Rahman Mahboob1ORCID,Still Carolyn H.11,Chen Zhengyi12ORCID,Tatsuoka Curtis12,

Affiliation:

1. From the Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center (J.T.W., M.R.), Case Western Reserve University, Cleveland, OH

2. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana (P.K.W.)

3. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J., W.C.C.)

4. Clinical Applications and Prevention Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (J.K.S., L.J.F., J.A.C.)

5. Department of Biostatistics and Data Science (D.M.R., N.M.P., W.T.A.) Wake Forest School of Medicine, Winston-Salem, NC

6. Section of Gerontology and Geriatric Medicine (J.D.W.), Wake Forest School of Medicine, Winston-Salem, NC

7. Renal Section, Veterans Affairs Salt Lake City Healthcare System, Utah (A.K.C., S.B.)

8. Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C., S.B.)

9. Department of Epidemiology (C.E.L.), University of Alabama at Birmingham

10. Section on Nephrology (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC

11. Frances Payne Bolton School of Nursing (C.H.S.), Case Western Reserve University, Cleveland, OH

12. Department of Medicine (S.O.), University of Alabama at Birmingham

Abstract

The SPRINT (Systolic Blood Pressure Intervention Trial) results have influenced clinical practice but have also generated discussion regarding the validity, generalizability, and importance of the findings. Following the SPRINT primary results manuscript in 2015, additional results and analyses of the data have addressed these concerns. The primary objective of this article is to respond to key questions that have been raised.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

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