Genome Scan for Blood Pressure Loci in Mice-Reference-Cited by-同舟云学术

Genome Scan for Blood Pressure Loci in Mice

Published:1999-10 Issue:4 Volume:34 Page:625-630
ISSN:0194-911X
Container-title:Hypertension
language:en
Short-container-title:Hypertension

Author:

Wright Fred A.¹,O’Connor Daniel T.¹,Roberts Elizabeth¹,Kutey Greg¹,Berry Charles C.¹,Yoneda Lisa U.¹,Timberlake David¹,Schlager Gunther¹

Affiliation:

1. From the Division of Human Cancer Genetics and the Comprehensive Cancer Center (F.A.W.), Ohio State University, Columbus, Ohio; the Department of Medicine and Center for Molecular Genetics (D.T.O., L.U.Y.), University of California and VA Healthcare System, San Diego; the Howard Hughes Medical Institute (E.R.), Division of Cellular and Molecular Medicine, University of California, San Diego; the Genetics Program (G.K., G.S.), University of Kansas, Lawrence; and the Department of Family and...

Abstract

Abstract —Hypertension is a complex trait of unknown cause in humans. Mice of the inbred strain BPH/2 serve as a rodent model of human hypertension and display elevated blood pressure compared with the hypotensive strain BPL/1. An F2 intercross of BPH/2 and BPL/1 and 2 backcrosses of BPL/1 with Mus spretus were used to perform interval linkage mapping for systolic blood pressure in a genome scan. Significant linkage was observed in the F2s on chromosome 10 (logarithm of the odds score [LOD]=4.9) and on chromosome 13 in the M spretus backcross (LOD=3.3), with additional suggestive LODs on chromosomes 2, 6, 8, and 18. In addition, several suggestive linkages were observed for phenotypes associated with human hypertension. Our study is the first reported genome-wide linkage scan for blood pressure genes in the mouse.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.34.4.625

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