1. From the Department of Biochemistry (T.Y., K.N., Y.Y., S.I., T.I.), Vanderbilt University School of Medicine, Nashville, Tenn; the 3rd Department of Internal Medicine (T.Y., H.S.) and Department of Dermatology (Y.Y.), Yokohama City University School of Medicine, Yokohama, Japan; Neurobiology of Aging Laboratories (S.T.), Mt. Sinai School of Medicine, New York, NY; and the Department of Anatomy and Physiology (E.D.M.), Meharry Medical College, Nashville, Tenn.