Evidence for Linkage Between Essential Hypertension and a Putative Locus on Human Chromosome 17-Reference-Cited by-同舟云学术

Evidence for Linkage Between Essential Hypertension and a Putative Locus on Human Chromosome 17

Published:1999-07 Issue:1 Volume:34 Page:4-7
ISSN:0194-911X
Container-title:Hypertension
language:en
Short-container-title:Hypertension

Author:

Baima Jader¹,Nicolaou Michael¹,Schwartz Faina¹,DeStefano Anita L.¹,Manolis Athanasios¹,Gavras Irene¹,Laffer Cheryl¹,Elijovich Fernando¹,Farrer Lindsay¹,Baldwin Clinton T.¹,Gavras Haralambos¹

Affiliation:

1. From the Department of Medicine, Hypertension Section (J.B., F.S., A.M., I.G., H.G.), Genetics Program (M.N., A.L. DeS., L.F.), Center for Human Genetics (C.T.B.), Department of Neurology (A.L. DeS., L.F.), and Department of Pediatrics (C.T.B.), Boston University School of Medicine, Boston, Mass; Department of Internal Medicine, Hypertension Section, University of Texas Medical Branch, Galveston, Tex (C.L., F.E.); and Department of Epidemiology and Biostatistics (M.N., A.L. DeS., L.F.), Boston...

Abstract

Abstract —Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environmental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory genes (quantitative trait loci) on rat chromosomes 2, 10, and X. In 1 human study of French and UK sib pairs, evidence for linkage has been reported to human chromosome 17q, the syntenic region of the rat chromosome 10 quantitative trait loci (QTL). Our study confirms this linkage ( P =0.0005) and refines the location of the blood pressure QTL.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.34.1.4

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