Affiliation:
1. From the Service de Médecine Interne, Hôpital Broussais, Paris (J.B., M.E.S.), and Service d’Hémodialyse, Hôpital F.H. Manhès, Fleury-Mérogis (B.P., A.P.G., S.J.M., G.M.L.), France.
Abstract
Abstract
—Damage of large arteries is a major contributory factor to the high pulse pressure observed in patients with end-stage renal disease. Whether incremental modulus of elasticity (E
inc
), a classic marker of arterial stiffness, can predict cardiovascular mortality has never been investigated. A cohort of 79 patients with end-stage renal disease undergoing hemodialysis was studied between September 1995 and January 1998. Mean age at entry was 58±15 years. The duration of follow-up was 25±7 months, during which 10 cardiovascular and 8 noncardiovascular fatal events occurred. At entry, carotid E
inc
was calculated from measurements of diameter, thickness (echo-tracking technique), and pulse pressure (tonometry). Based on Cox analyses, 2 dominant factors emerged as predictors of all-cause and cardiovascular mortality: increased E
inc
and decreased diastolic blood pressure. Lipid abnormalities and the presence of previous cardiovascular events interfered to a smaller extent. After adjustment for confounding variables, the odds ratio for E
inc
≥1 kPa
−3
was 9.2 (95% confidence interval, 2.4 to 35.0) for all-cause mortality. These results provide the first direct evidence that in patients with end-stage renal disease undergoing hemodialysis, arterial alterations, as determined from carotid E
inc
, are strong independent predictors of all-cause and cardiovascular mortality.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference32 articles.
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