Affiliation:
1. From the Department of Medicine, Division of Cardiology, Weill Medical College of Cornell University (P.M.O., R.B.D.), New York, NY; Sahlgrenska University Hospital/Östra (S.J., B.D.), Göteborg, Sweden; Ullevål University Hospital (S.E.K.), Oslo, Norway; and University of Michigan Medical Center (S.J.), Ann Arbor, Mich.
Abstract
Abstract
—The Losartan Intervention For Endpoint (LIFE) reduction in hypertension study is a double-blind, prospective, parallel group study designed to compare the effects of losartan with those of atenolol on the reduction of cardiovascular morbidity and mortality. A total of 9194 patients with hypertension and ECG left ventricular hypertrophy (LVH) by Cornell voltage-duration product and/or Sokolow-Lyon voltage criteria were enrolled in the study, with baseline clinical and ECG data available in 8785 patients (54% women; mean age, 67±7 years). ECG LVH by Cornell voltage-duration product criteria was present in 5791 patients (65.9%) and by Sokolow-Lyon voltage in 2025 patients (23.1%). Compared with patients without ECG LVH by Cornell voltage-duration product criteria, patients with ECG LVH by this method were older; more obese; more likely to be female, white, and to have never smoked; more likely to be diabetic and have angina; and had slightly higher systolic, diastolic, and pulse blood pressures. In contrast, patients with ECG LVH by Sokolow-Lyon criteria were slightly younger; less obese; more likely to be male, black, and current smokers; less likely to have diabetes; more likely to have angina and a history of cerebrovascular disease; and had higher systolic and pulse blood pressure but slightly lower diastolic blood pressure than patients without ECG LVH by this method. By use of multivariate logistic regression analyses, presence of ECG LVH by Cornell voltage-duration product criteria was predominantly associated with higher body mass index, increased age, and female gender, whereas presence of ECG LVH by Sokolow-Lyon voltage criteria was predominantly related to lower body mass index, male gender, and black race. Thus, hypertensive patients who meet Cornell product and Sokolow-Lyon voltage criteria are associated with different, but potentially equally adverse, risk factor profiles.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference36 articles.
1. Dahlöf B Devereux R de Faire U Fyhrquist F Hedner T Ibsen H Julius S Kjeldsen S Kristianson K Lederballe-Pedersen O Lindholm LH Nieminen MS Omvik P Oparil S Wedel H for the LIFE Study Group. The Losartan Intervention For Endpoint reduction (LIFE) in Hypertension Study: rationale design and methods. Am J Hypertens . 1997;10(pt 1):705–713.
2. Apical wall stress by finite element analysis predicts subsequent left ventricular remodeling in the healing and early afterload reducing trial
3. Left Ventricular Hypertrophy by Electrocardiogram
4. Electrocardiographic Left Ventricular Hypertrophy and Risk of Coronary Heart Disease
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