Author:
Yukimura T,Stock G,Stumpf H,Unger T,Ganten D
Abstract
Effects of intracerebroventricular (i.c.v) injection of [D-Ala2]-methionine-enkephalinamide (DAME) on blood pressure (BP), heart rate, and baroreceptor reflex sensitivity were studied in conscious cats. DAME was administered at doses between 5 and 100 nmoles. Blood pressure and heart rate increased dose dependently. The sensitivity of the baroreceptor reflex was attenuated for 15 to 60 minutes after DAME administration; this was independent of the BP changes. The effects of enkephalin on BP and baroreceptor reflex were abolished by i.c.v. naloxone. DAME caused pathological changes in the electroencephalogram (EEG) characterized by sharp waves in the hippocampus recordings and a loss of theta activity in the electrocorticogram. Behavioral changes were characterized by decreased physical mobility and anxiousness. These behavioral and EEG changes lasted for a longer period of time than the cardiovascular changes; they were also counteracted by naloxone. It is concluded that DAME produces a centrally mediated vasopressor response and a baroreceptor reflex attenuation and that, with respect to the time course, the effects on the baroreceptor reflex are separated from those on BP behavior and EEG, but not on heart rate. The fact that all effects of enkephalin on the parameters tested in the present experiment were completely antagonized by naloxone suggests that they are mediated by naloxone-sensitive enkephalin brain receptors.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference32 articles.
1. Ganten D Unger T Rockhold R Schaz K Speck G: Central peptidergic stimulation: Its possible contribution to blood pressure regulation. In Radioimmunoassay of Drugs and Hormones in Cardiovascular Medicine edited by Albertini A Da Prada M Peskar BA. Amsterdam: Elsevier 1979 p 33
2. Cardiovascular effects of morphine and opioid peptides following intracisternal administration in chloralose-anesthetized rats
3. Humoral and neurohormonal aspects of blood pressure regulation: Focus on angiotensin
4. Effects of angiotensin on the central nervous system;Severs WB;Pharmacol Rev,1973
5. Unger T Rockhold RW Yukimura T Rettig R Rascher W Ganten D: The possible role of kinins and substance P in blood pressure regulation of normotensive and spontaneously hypertensive rats. In Central Nervous System Mechanisms in Hypertension edited by Buckley JP Ferrario CM. New York: Raven Press. In press
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