Relationship Between Adrenergic Activity and Cardiac Actions of Quinidine

Author:

Roberts Jay1,Stadter Richard P.1,Cairoli Vincent1,Madell Walter1

Affiliation:

1. Department of Pharmacology, Cornell University Medical College, New York, New York

Abstract

Unanesthetized dogs with complete heart block were used to explore the relationship between adrenergic activity and quinidine action on the heart. After vagolysis, quinidine still increased both the atrial and ventricular rates. Following reduction in adrenergic activity by reserpine, hexamethonium, or surgical sympathectomy, the atrial and ventricular pacemakers were depressed. After sympathetic activity had been reduced by a combination of hexamethonium and reserpine, quinidine caused profound pacemaker depression and sometimes ventricular asystole. Quinidine produced coupling and occasionally runs of ventricular tachycardia independent of the level of sympathetic activity. There was no significant prolongation of the QRS time by quinidine in doses of 5 and 10 mg./Kg. Both the development of ectopic pacemakers and the depression of pacemaker activity of quinidine were dose dependent.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference14 articles.

1. : Intorno all' antagonismo della chinina con le sostanze adrenalinosimili;MANCINI M. A.;Boll. Soc. Ital. Biol. Sper.,1940

2. DEPRESSION OF THE HEART BY QUINIDINE AND ITS TREATMENT

3. Adams-Stokes syndrome

4. NICKEL S. N. AND THIBAUDEAU Y.: Quinidine intoxication treated by isoproterenol. Canad. M. A. .1. 85: 81 1961.

5. Method for the evaluation of depressants of subatrial rhythmic function in the heart of the intact animal;ROBERTS J.;J. Pharmacol. & Exper. Therap.,1960

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