Affiliation:
1. Hypertension Research Unit, Centro de Investigaciones Cardiológicas, University of Buenos Aires Medical School Buenos Aires, Argentina
Abstract
The increased peripheral resistance responsible for hypertension associated with unilateral renal ischemia and contralateral nephrectomy, is abolished after destruction by pithing of the central nervous system of dogs and rats, or after inactivation of the inhibitory carotid sinus reflex in dogs. The tissue catecholamine content of renal hypertensive rats was in the same range as in the normotensive animals. These results suggest that the increased peripheral resistance in hypertension is neurogenically mediated and that the increased resistance is due to an increased response of the resistance vessels to normal neurogenic stimulation.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
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18 articles.
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