1. From the SINAPSE Collaboration (J.M.W.), SFC Brain Imaging Research Centre, Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK; the Department of Clinical Sciences (V.M.), Karolinska Institutet Danderyd Hospital, Stockholm, Sweden; the Division of Internal Medicine (E.B.), Oslo University Hospital, Oslo, Norway; and the Department of Medicine and Neurology (G.J.d.Z.), University of Washington, Harborview Medical Center, Seattle, Wash.