Circadian Biology and Stroke

Author:

Lo Eng H.12ORCID,Albers Gregory W.13,Dichgans Martin145,Donnan Geoffrey16,Esposito Elga12,Foster Russell17ORCID,Howells David W.18ORCID,Huang Yi-Ge19ORCID,Ji Xunming110ORCID,Klerman Elizabeth B.111ORCID,Lee Sarah13,Li Wenlu12ORCID,Liebeskind David S.112,Lizasoain Ignacio113ORCID,Mandeville Emiri T.12,Moro Maria A.114ORCID,Ning MingMing111,Ray David115ORCID,Sakadžić Sava12,Saver Jeffrey L.112,Scheer Frank A.J.L.116,Selim Magdy117,Tiedt Steffen15,Zhang Fang12,Buchan Alastair M.19ORCID

Affiliation:

1. CIRCA consortium (E.H.L., G.W.A., M.D., G.D., E.E., R.F., D.W.H., Y-G.H., X.J., E.B.K., S.L., W.L., D.S.L., I.L., E.T.M., M.A.M., M.N., D.R., S.S., J.L.S., F.A.J.L.S., M.S., S.T., F.Z., A.M.B.), Massachusetts General Hospital, Harvard Medical School, Boston.

2. Departments of Radiology (E.H.L., E.E., W.L., E.T.M., S.S., F.Z.), Massachusetts General Hospital, Harvard Medical School, Boston.

3. Department of Neurology, Stanford Stroke Center, Stanford University, Palo Alto (G.W.A., S.L.).

4. German Center for Neurodegenerative Diseases (DZNE, Munich) and Munich Cluster for Systems Neurology (SyNergy), Germany (M.D.).

5. Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany (M.D., S.T.).

6. Departments of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Australia (G.D.).

7. Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences (R.F.), University of Oxford, United Kingdom.

8. Tasmanian School of Medicine, University of Tasmania, Australia (D.W.H.).

9. Department of Stroke Medicine (Y.H., A.M.B.), University of Oxford, United Kingdom.

10. Beijing Institute for Brain Disorders, China (X.J.).

11. Neurology (E.B.K., M.N.), Massachusetts General Hospital, Harvard Medical School, Boston.

12. Department of Neurology, Geffen School of Medicine, University of California Los Angeles (J.L.S., D.S.L.).

13. Department of Pharmacology and Toxicology, Complutense Medical School, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain (I.L.).

14. Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain (M.A.M.).

15. NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, and Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom (D.R.).

16. Departments of Medicine and Neurology, Brigham & Women’s Hospital (F.A.J.L.S.), Harvard Medical School, Boston.

17. Department of Neurology, Beth Israel Deaconess Medical Center (M.S.), Harvard Medical School, Boston.

Abstract

Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology

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