1. From the Department of Internal Medicine (C.A.A.), Division of Cardiovascular Diseases (C.J.M., B.J.G.), and Section of Biostatistics (S.S.C.), Mayo Clinic, Rochester, MN; Division of Cardiology, Department of Medicine, The University British Columbia, Vancouver, British Columbia, Canada (T.S.M.T.); and University Department of Medicine, University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.).