1. From the Cardiovascular Research Center (Q.L., D.A., S.K., J.E., A.W., P.L.H.) and Neuroprotection Research Laboratory (E.M., K.H., E.H.L.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; the Departments of Anesthesiology and Molecular, Pharmacology, and Experimental Therapeutics, Mayo Clinic, Rochester, MN (L.V.U., Z.K.); and the Department of Pharmacology and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT (W.S.).