1. From the Massachusetts General Hospital, Boston (E.R.M.); National University of Ireland, Galway, Ireland (E.R.M.); University of Toronto, Toronto, Ontario, Canada (M.K.K.); Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada (M.K.K., J.F.); McMaster University, Hamilton, Ontario, Canada (J.W.E.); and National University of Ireland, Galway, Ireland (A.O.C., M.C., M.J.O.).