Admission Blood Pressure in Relation to Clinical Outcomes and Successful Reperfusion After Endovascular Stroke Treatment
Author:
van den Berg Sophie A.1ORCID, Uniken Venema Simone M.2ORCID, Mulder Maxim J.H.L.3, Treurniet Kilian M.4ORCID, Samuels Noor5, Lingsma Hester F.5, Goldhoorn Robert-Jan B.6ORCID, Jansen Ivo G.H.4, Coutinho Jonathan M.1, Roozenbeek Bob37, Dippel Diederik W.J.3, Roos Yvo B.W.E.M.1, van der Worp H. Bart2, Nederkoorn Paul J.1, van der Lugt Aad, Majoie Charles B.L.M., van Oostenbrugge Robert J., van Zwam Wim H., Vos Jan Albert, Brouwer Josje, den Hartog Sanne J., Hinsenveld Wouter H., Kappelhof Manon, Compagne Kars C.J., van der Lugt Aad, van Es Adriaan C.G.M., Majoie Charles B.L.M., Emmer Bart J., Schonewille Wouter J., Vos Jan Albert, Wermer Marieke J.H., van Walderveen Marianne A.A., Staals Julie, van Oostenbrugge Robert J., van Zwam Wim H., Hofmeijer Jeannette, Martens Jasper M., Lycklama à Nijeholt Geert J., Boiten Jelis, de Bruijn Sebastiaan F., van Dijk Lukas C., Lo Rob H., van Dijk Ewoud J., Boogaarts Hieronymus D., de Vries J., de Kort Paul L.M., van Tuijl Julia, Peluso Jo P., Fransen Puck, van den Berg Jan S.P., van Hasselt Boudewijn A.A.M., Aerden Leo A.M., Dallinga René J., Uyttenboogaart Maarten, Eschgi Omid, Bokkers Reinoud P.H., Schreuder Tobien H.C.M.L., Heijboer Roel J.J., Keizer Koos, Yo Lonneke S.F., den Hertog Heleen M., Sturm Emiel J.C., Brouwers Paul, Majoie Charles B.L.M., van Zwam Wim H., van der Lugt Aad, Lycklama à Nijeholt Geert J., van Walderveen Marianne A.A., Sprengers Marieke E.S., Jenniskens Sjoerd F.M., van den Berg René, Yoo Albert J., Beenen Ludo F.M., Postma Alida A., Roosendaal Stefan D., van der Kallen Bas F.W., van den Wijngaard Ido R., van Es Adriaan C.G.M., Emmer Bart J., Martens Jasper M., Yo Lonneke S.F., Vos Jan Albert, Bot Joost, van Doormaal Pieter-Jan, Meijer Anton, Ghariq Elyas, Bokkers Reinoud P.H., van Proosdij Marc P., Krietemeijer G. Menno, Peluso Jo P., Boogaarts Hieronymus D., Lo Rob, Gerrits Dick, Dinkelaar Wouter, Appelman Auke P.A., Hammer Bas, Pegge Sjoert, van der Hoorn Anouk, Vinke Saman, van der Lugt Aad, Majoie Charles B.L.M., van Oostenbrugge Robert J., van Zwam Wim H., Lycklama à Nijeholt Geert J., Boiten Jelis, Vos Jan Albert, Schonewille Wouter J., Hofmeijer Jeannette, Martens Jasper M., Lo Rob H., van Oostenbrugge Robert J., Hofmeijer Jeannette, Flach H. Zwenneke, Ghannouti Naziha el, Sterrenberg Martin, Puppels Corina, Pellikaan Wilma, Sprengers Rita, Elfrink Marjan, Simons Michelle, Vossers Marjolein, de Meris Joke, Vermeulen Tamara, Geerlings Annet, van Vemde Gina, Simons Tiny, van Rijswijk Cathelijn, Messchendorp Gert, Nicolaij Nynke, Bongenaar Hester, Bodde Karin, Kleijn Sandra, Lodico Jasmijn, Droste Hanneke, Wollaert Maureen, Verheesen Sabrina, Jeurrissen D., Bos Erna, Drabbe Yvonne, Sandiman Michelle, Elfrink Marjan, Aaldering Nicoline, Zweedijk Berber, Khalilzada Mostafa, Vervoort Jocova, Droste Hanneke, Nicolaij Nynke, Simons Michelle, Ponjee Eva, Romviel Sharon, Kanselaar Karin, Bos Erna, Barning Denn, Venema Esmee, Chalos Vicky, Geuskens Ralph R., van Straaten Tim, Ergezen Saliha, Harmsma Roger R.M., Muijres Daan, de Jong Anouk, Berkhemer Olvert A., Boers Anna M.M., Huguet J., Groot P.F.C., Mens Marieke A., van Kranendonk Katinka R., Tolhuisen Manon L., Alves Heitor, Weterings Annick J., Kirkels Eleonora L.F., Voogd Eva J.H.F., Schupp Lieve M., Collette Sabine, Groot Adrien E.D., LeCouffe Natalie E., Konduri Praneeta R., Prasetya Haryadi, Arrarte-Terreros Nerea, Ramos Lucas A.
Affiliation:
1. Department of Neurology (S.A.v.d.B., J.M.C., Y.B.W.E.M.R., P.J.N.), Amsterdam University Medical Center, University of Amsterdam, the Netherlands. 2. Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, the Netherlands (S.M.U.V., H.B.v.d.W.). 3. Department of Neurology (M.J.H.L.M., B.R., D.W.J.D.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands. 4. Department of Radiology (K.M.T., I.G.H.J.), Amsterdam University Medical Center, University of Amsterdam, the Netherlands. 5. Department of Public Health (N.S., H.F.L.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands. 6. Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands (R.-J.B.G.). 7. Department of Radiology and Nuclear Medicine (B.R.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Abstract
Background and Purpose:
Optimal blood pressure (BP) targets before endovascular treatment (EVT) for acute ischemic stroke are unknown. We aimed to assess the relation between admission BP and clinical outcomes and successful reperfusion after EVT.
Methods:
We used data from the MR CLEAN (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Registry, an observational, prospective, nationwide cohort study of patients with ischemic stroke treated with EVT in routine clinical practice in the Netherlands. Baseline systolic BP (SBP) and diastolic BP (DBP) were recorded on admission. The primary outcome was the score on the modified Rankin Scale at 90 days. Secondary outcomes included successful reperfusion (extended Thrombolysis in Cerebral Infarction score 2B-3), symptomatic intracranial hemorrhage, and 90-day mortality. Multivariable logistic and linear regression were used to assess the associations of SBP and DBP with outcomes. The relations between BPs and outcomes were tested for nonlinearity. Parameter estimates were calculated per 10 mm Hg increase or decrease in BP.
Results:
We included 3180 patients treated with EVT between March 2014 and November 2017. The relations between admission SBP and DBP with 90-day modified Rankin Scale scores and mortality were J-shaped, with inflection points around 150 and 81 mm Hg, respectively. An increase in SBP above 150 mm Hg was associated with poor functional outcome (adjusted common odds ratio, 1.09 [95% CI, 1.04–1.15]) and mortality at 90 days (adjusted odds ratio, 1.09 [95% CI, 1.03–1.16]). Following linear relationships, higher SBP was associated with a lower probability of successful reperfusion (adjusted odds ratio, 0.97 [95% CI, 0.94–0.99]) and with the occurrence of symptomatic intracranial hemorrhage (adjusted odds ratio, 1.06 [95% CI, 0.99–1.13]). Results for DBP were largely similar.
Conclusions:
In patients with acute ischemic stroke treated with EVT, higher admission BP is associated with lower probability of successful reperfusion and with poor clinical outcomes. Further research is needed to investigate whether these patients benefit from BP reduction before EVT.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology
Cited by
32 articles.
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