Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?-Reference-Cited by-同舟云学术

Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?

Published:2022-04 Issue:4 Volume:53 Page:1411-1422
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Taha Aladdin¹²^ORCID,Bobi Joaquim¹^ORCID,Dammers Ruben³^ORCID,Dijkhuizen Rick M.⁴^ORCID,Dreyer Antje Y.⁵^ORCID,van Es Adriaan C.G.M.⁶^ORCID,Ferrara Fabienne⁷,Gounis Matthew J.⁸^ORCID,Nitzsche Björn⁹¹⁰^ORCID,Platt Simon¹¹,Stoffel Michael H.¹²^ORCID,Volovici Victor³^ORCID,del Zoppo Gregory J.¹³¹⁴¹⁵,Duncker Dirk J.¹^ORCID,Dippel Diederik W.J.²^ORCID,Boltze Johannes¹⁶^ORCID,van Beusekom Heleen M.M.¹^ORCID

Affiliation:

1. Division of Experimental Cardiology, Department of Cardiology (A.T., J.B., D.J.D., H.M.M.v.B.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.

2. Department of Neurology, Stroke Center (A.T., D.W.J.D.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.

3. Department of Neurosurgery, Stroke Center (R.D., V.V.), Erasmus MC University Medical Center, Rotterdam, the Netherlands.

4. Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, the Netherlands (R.M.D.).

5. Max Planck Institute for Infection Biology, Campus Charité Mitte, Berlin, Germany (A.Y.D.).

6. Department of Radiology, Leiden University Medical Center, the Netherlands (A.C.G.M.v.E.).

7. Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany (F.F.).

8. Department of Radiology, New England Center for Stroke Research, University of Massachusetts Medical School, Worcester (M.J.G.).

9. Institute of Anatomy, Faculty of Veterinary Medicine (B.N.), University of Leipzig, Germany.

10. Department of Nuclear Medicine (B.N.), University of Leipzig, Germany.

11. Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens (S.P.).

12. Division of Veterinary Anatomy, Vetsuisse Faculty, University of Bern, Switzerland (M.H.S.).

13. Division of Hematology (G.J.d.Z.), University of Washington School of Medicine, Seattle.

14. Department of Medicine (G.J.d.Z.), University of Washington School of Medicine, Seattle.

15. Department of Neurology (G.J.d.Z.), University of Washington School of Medicine, Seattle.

16. School of Life Sciences, Faculty of Science, University of Warwick, Coventry, United Kingdom (J.B.).

Abstract

Translation of acute ischemic stroke research to the clinical setting remains limited over the last few decades with only one drug, recombinant tissue-type plasminogen activator, successfully completing the path from experimental study to clinical practice. To improve the selection of experimental treatments before testing in clinical studies, the use of large gyrencephalic animal models of acute ischemic stroke has been recommended. Currently, these models include, among others, dogs, swine, sheep, and nonhuman primates that closely emulate aspects of the human setting of brain ischemia and reperfusion. Species-specific characteristics, such as the cerebrovascular architecture or pathophysiology of thrombotic/ischemic processes, significantly influence the suitability of a model to address specific research questions. In this article, we review key characteristics of the main large animal models used in translational studies of acute ischemic stroke, regarding (1) anatomy and physiology of the cerebral vasculature, including brain morphology, coagulation characteristics, and immune function; (2) ischemic stroke modeling, including vessel occlusion approaches, reproducibility of infarct size, procedural complications, and functional outcome assessment; and (3) implementation aspects, including ethics, logistics, and costs. This review specifically aims to facilitate the selection of the appropriate large animal model for studies on acute ischemic stroke, based on specific research questions and large animal model characteristics.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)

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