Affiliation:
1. From the Cardiovascular Section, Medical Service, Walter Reed Army Hospital, and the Army, Medical Service Graduate School.
Abstract
Dibenzyline is an orally effective, moderately potent, long acting, adrenergic blocking agent. The drug is capable of at least partially preventing the vasoconstrictor responses to cold and to injected Neosynephrine. Blood flow and temperature responses to this agent do not always parallel results obtained following surgical sympathectomy, but the degree of effect appears to be sufficient to produce a clinical response. Side effects and the development of "tolerance" may limit the use of Dibenzyline in clinical medicine.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference9 articles.
1. Oral and intravenous adrenolytic activity of a number of N-benzyl-N-phenoxyethyl and N-benzyl-N-phenoxyisopropyl-beta-chloroethylamines;MACKO E.;J. Pharmacol. & Exper. Therap.,1951
2. Studies on N-phenoxyisopropyl-benzyl-beta-chloroethylamine, an o'ally effective adrenergic blocking agent;MCLEAN R. A.;J. Pharmacol. & Exper. Therap.,1951
3. HAIMOVICI H. MOSER M. AND KRAKAUER H.: Effect of oral 688A (N-phenoxyisopropyl-Nbenzyl-beta-chloroethylamine hydrochloride) on blood pressure in normotensive and hypertensive subjects. Proc. Soc. Exper. Biol. & 'led. 77: 477 1951.
4. Clinical Applications of Adrenergic Blockade in Vascular Diseases With Special Reference To Dibenamine and 688a
5. MOSER M. PRANDONI A. G. ORBIsoN J. A. AND MATTINGLY T. W.: Clinical experience with sympathetic blocking agents in peripheral vascular disease. To be published.
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