The Hemodynamic Effects of Hypotensive Drugs in Man-Reference-Cited by-同舟云学术

The Hemodynamic Effects of Hypotensive Drugs in Man

Published:1953-08 Issue:2 Volume:8 Page:199-204
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

FREIS EDWARD D.¹,ROSE JOHN C.¹,HIGGINS THOMAS F.¹,FINNERTY FRANK A.¹,KELLEY ROBERT T.¹,PARTENOPE EDWARD A.¹

Affiliation:

1. From the Cardiovascular Research Laboratory, Georgetown University Hospital; the Department of Medicine, Georgetown University School of Medicine; the Veterans Administration Hospital, Washington, D. C.; and the Georgetown Medical Division, Gallinger Municipal Hospital, Washington, D. C.

Abstract

Further data are presented concerning the unusual hemodynamic effects of 1-hydrazinophthalazine. Previous observations demonstrating a marked increase in cardiac output in normotensive subjects are confirmed in hypertensive patients. The splanchnic vascular bed is one of the sites of increased blood flow. The similarity between the hemodynamic effects of 1-hydrazinophthalazine and pyrogens is pointed out and the pharmacologic basis for the clinically observed additive effects of 1-hydrazinophthalazine and hexamethonium is discussed.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.8.2.199

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5. Cardiovascular and renal adjustments to a hypotensive agent (1-hydrazinophthalazine: Ciba BA-5968: Apresoline);XWILKINSON E. L.;J. Clin. Investigation,1952

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