Thrombelastographic Studies with a Twenty-Four-Hour Schedule for Subcutaneous Heparin

Abstract

In 55 patients 430 thrombelastographic studies after 305 heparin injections revealed that a more complete and more rapid reduction of the over-all coagulability of the blood is obtained by a subcutaneous injection of 40 per cent heparin once every 24 hours than that obtained with prothrombin-depressing agents. The individual dose, by the thrombelastographic technic, is between 3.5 and 4.5 mg./Kg. Further clinical studies are indicated with use of simple laboratory control technics, such as recalcification time.