Hormones, Cholesterol, and Coronary Atherosclerosis

Author:

KURLAND GEORGE S.1,FREEDBERG A. STONE1

Affiliation:

1. From the Department of Medicine of the Harvard Medical School, and the Medical Research Department and the Medical Service, Yamins Research Laboratory, Beth Israel Hospital, Boston, Mass.

Abstract

Various hormones have been shown to play an important role in lipid metabolism. Clinical and experimental observations implicate the thyroid, adrenal, gonadal, and pituitary glands in atherogenesis. The evidence is strongest that estrogens play a role in human atherosclerosis. The influence of hypothyroidism requires further study and clarification. Hormones and lipids are obviously not the only factors important in atherogenesis; hypertension, local tissue factors, and altered intravascular coagulation in all probability significantly influence the natural history of the disease.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference83 articles.

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2. British Medical Journal 14: No. 3 September 1958. G. Popjak Ed. Published by the Medical Departmieint the British Council London Wl.

3. Symposium oni Atherosclerosis. The National Academy of Sciences. National Research Council Publicationi #338 Washington D. C. 1959.

4. Influence of sex and sex hormones upon the development of atherosclerosis and upon the lipoproteins of plasma

5. Blood Cholesterol Values in Hyperthyroidism and Hypothyroidism — Their Significance

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