Importance of Amino Acid Side Groups for Biologic Activity of Angiotensin II-Reference-Cited by-同舟云学术

Importance of Amino Acid Side Groups for Biologic Activity of Angiotensin II

Published:1962-01 Issue:1 Volume:25 Page:183-185
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

BUMPUS F. M.¹,SMEBY R. R.¹

Affiliation:

1. From the Research Division of the Cleveland Clinic Foundation and the Frank E. Bunts Educational Institute, Cleveland, Ohio.

Abstract

The requirements for biologic activity of angiotensin II may be summarized from available data as follows: (1) a free C-terminal carboxyl group, (2) a phenyl group as a side group of amino acid number 8, (3) a phenolic group on amino acid number 4, (4) proline in position 7, (5) possibly a definite degree of spatial order, (6) at least 6 amino acids from the C-terminus, (7) possibly the imidazole of histidine in position 6.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.25.1.183

Reference6 articles.

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2. BUMPUS F. M. KHAIRALLAH P. A. ARAKAWA K. PAGE I H. AND SMEBY R. R.: Relationship of structure to pressor and oxytocic actions of isoleucine-5 angiotensin octapeptide and various analogues. Biochem. et biophys. acta 46: 38 1961.

3. GROss F. AND TURRIAN H.: Pharmacology of hypertensin and synthetic aiialogues. In Polypeptides Which Affect Smooth Muscles and Blood Vessels edited by M. Schacter. New York Pergamon Press 1960.

4. Synthetic pathways to naturally occurring peptides;SCHWYZER R.;Record of Chem. Progr.,1959

5. PAIVA A. C. M. AND PAIVA T. B.: Photooxidative inactivation of angiotensin amide. Biochem. et biophys. acta 48: 412 1961.

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