Angiotensin II Studies in Hypertension

Abstract

1. In primary hypertension, the digital blood vessels are more reactive than normal to angiotensin II as well as to l -norepinephrine. 2. In terms of weight, the potency of angiotensin II in constricting digital blood vessels is 10 times that of norepinephrine in both normotensive and hypertensive subjects. 3. The turnover of angiotensin II-I 131 is slower than normal in patients with primary hypertension. 4. Digital vascular reactivity to both l -norepinephrine and angiotensin II is normal in "pure" renal hypertension. 5. Angiotensin II-I 131 turnover, in contrast, in the case of renal hypertension studied, was slower than in the normal group and was similar to that in the case of primary hypertension.