Renal Hemodynamic Effects of Total Cardiopulmonary Bypass Eliminating Heparinized Blood

Abstract

In order to compare the renal hemodynamic effects of using 5 per cent dextrose in distilled water with the effects of using fresh, heparinized blood as the priming agent for extracorporeal circulation, mongrel dogs were subjected to 30 minutes of total cardiopulmonary bypass by each technique. Discrete renal function determinations were performed before and after bypass. In one group, homologous blood was used to prime the pump oxygenator. Renal function in these animals was depressed to approximately two-thirds of control values. In the other group, 5 per cent dextrose in distilled water was used as the priming agent. In these animals, little or no change in renal function was noted following operation, indicating more optimal maintenance of renal function by this technique.