General Circulatory Alterations Induced by Intravenous Infusion of Synthetic Bradykinin in Man-Reference-Cited by-同舟云学术

General Circulatory Alterations Induced by Intravenous Infusion of Synthetic Bradykinin in Man

Published:1964-01 Issue:1 Volume:29 Page:66-70
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

DE FREITAS FLAVIO M.¹,FARACO EDUARDO Z.¹,DE AZEVEDO DECIO F.¹

Affiliation:

1. From the Cardio-Pulmonary Laboratory, Department of Clinical Therapeutics (Eduardo Z. Faraco, M.D., Chief), Pôrto Alegre Medical School, University of Rio Grande do Sul, Brazil.

Abstract

The general hemodynamic effects induced by a continuous intravenous infusion of synthetic bradykinin were studied in ten patients submitted to simultaneous right- and left-heart catheterization. A significant drop in systemic arterial pressure and in total peripheral resistance was observed, coincident with an increase of the cardiac output, heart rate, and stroke volume. There was no consistent change of the pulmonary arterial and left atrial pressures, but the pulmonary vascular resistance decreased significantly.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.29.1.66

Reference21 articles.

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3. The isolation of bradykinin: A plasma kinin from ox blood;ELLIOTT D. F.;Biochem. J.,1960

4. Synthesis and biological activity of peptides related to bradykinin

5. The structure of bradykinin — A plasma kinin from ox blood

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