Affiliation:
1. From the Mount Zion Hospital, Harold Brunn Institute for Cardiovascular Research, San Francisco, Calif.
Abstract
By employing the embryonic duck heart method to assay digitoxin quantitatively in extracts of human urine, it was found that, contrary to previous opinion, a large percentage of ingested or in-injected digitoxin is excreted via the kidney in a physiologically active state. Approximately 40 per cent of a digitalizing dose (1.2 mg.) is excreted over a period of 12 to 24 days. The average rate of renal excretion in theoretically digitalized normal young individuals was found to vary from 30 to 50 µg. of digitoxin per day, while those showing signs or symptoms of overdosage excreted significantly greater amounts of digitoxin.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference8 articles.
1. Studies in the elimination of certain of the digitalis bodies from the animal organism;HATCHER R. A.;J. Pharmacol. & Exper. Therap.,1919
2. Employment of the Embryonic Duck Heart for the Detection of Minute Amounts of a Digitalis Glycoside (Lanatoside G)
3. Urinary Excretion of Digitoxin in the Rat.
4. Renal excretion of digitoxin in man followinig
5. oral administration. Proc. Soc. Exper. Biol. &
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