Blood Capillaries of the Heart and Other Organs

Author:

Kossmann Charles E.1,PALADE GEORGE E.1

Affiliation:

1. From the Rockefeller Institute for Medical Research, New York, New York.

Abstract

The article is a review of work recently carried out on blood capillaries by the author in collaboration with Drs. M. G. Farquhar, G. Majno, and S. L. Wissig. It reviews the morphology of these vessels at the electron-microscope level and confirms the existence of at least 3 distinct types of blood capillaries in small laboratory mammals. It shows that the capillary wall consists of 3 concentric layers (endothelium, basement membrane, and adventitia), and indicates that the basement membrane forms a continuous layer in all capillaries so far studied. Experiments in which colloidal gold particles were used as a tracer have shown that, in capillaries with a continuous endothelium (muscle capillaries), the particles are transported across it by "pinocytic" vesicles. At the end of this step they must still transverse the basement membrane. Experiments on glomerular capillaries, which typically have a discontinuous s endothelium, were carried out on normal and nephrotic rats using ferritin as a tracer. By its accumulation on the luminal side of the basement membrane, the ferritin has identified this layer as the main filtration barrier. A similar function of the basement membrane was demonstrated in muscle venules and venous capillaries by experiments in which the endothelium was rendered discontinuous by local treatment with histamine and serotonin.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Cited by 211 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3