Myocardial Response to Cigarette Smoking in Normal Subjects and Patients with Coronary Disease

Author:

REGAN T. J.1,FRANK M. J.1,MCGINTY J. F.1,ZOBL E.1,HELLEMS H. K.1,BING R. J.1

Affiliation:

1. From the Department of Medicine, Wayne State University, College of Medicine, Detroit, Michigan.

Abstract

The myocardial and peripheral hemodynamic effects of cigarette smoking have been assessed during a steady state situation in a group of normal subjects, and compared with a group of patients with coronary artery disease. During smoking, in both groups there was augmentation of heart rate, systemic arterial pressure, and left ventricular work, this response being somewhat greater in the coronary patients. Despite these hemodynamic alterations, neither group had a significant change in coronary blood flow, so that myocardial oxygen usage remained virtually identical with the value before smoking. There was no evidence of myocardial ischemia in the coronary subjects during smoking. The various factors, potentially responsible for the lack of myocardial blood flow increment are considered.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference16 articles.

1. HEYMAN C. BOUCKART J. J. AND DANTREBUNDE L.: Sinus carotidien et reflexes respiratoires. III. Sensibilite des sinus carotidien aux substances chemiques. Action stimulante respiratoire reflexe du sulfure de sodium du cyanure de potassium de la nicotine et de la lobeline. Arch. internat. pharmacodyn. 40: 54 1931.

2. Pituri and Nicotin

3. Observations on the role of the adrenal medulla in blood pressure response to nicotine;VAN SLYKE C. B.;J. Pharmacol. & Exper. Therap.,1950

4. The antidiuretic response to and excretion of pituitary (posterior lobe) extract in man, with reference to the action of nicotine;BURN G. P.;Brit. J. Pharmacol.,1951

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1. REFERENCES;Acta Medica Scandinavica;2009-04-24

2. Timothy J. Regan;Clinical Cardiology;2003-11

3. Cigarette smoking and coronary blood flow;Progress in Cardiovascular Diseases;2003-04

4. Effects of Nicotine Gum on Coronary Vasomotor Responses During Sympathetic Stimulation in Patients with Coronary Artery Stenosis;Journal of Cardiovascular Pharmacology;1999-11

5. How smoking affects blood pressure;Blood Pressure;1996-01

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