Plasma Heparin Levels

Author:

ENGELBERG H.1

Affiliation:

1. From the Division of Pathology, Cedars of Lebanon Hospital, Los Angeles, California.

Abstract

Endogenous plasma heparin was determined in 147 males and 113 females. Serum cholesterol was measured in the entire group, and low-density lipoproteins were ultracentrifugally analyzed in 131 males aud 77 females. Statistical analysis of the data showed a definitely significant ( p <.01) negative correlation between heparin on the one hand and serum cholesterol and Sf 12-400 lipoproteins on the other in males. In females the correlation between heparin and cholesterol was negative but fell short of the 5 per cent level of significance. The correlation between heparin and Sf 12-400 lipoproteins was negative and statistically definitely significant ( p <.01). The correlation with the Sf 0-12 lipoproteins was also negative and probably significant ( p <.05). These results afford substantial evidence that a relative deficiency of circulating heparin rin is one of the important causative factors leading to elevated levels of serum lipid.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference20 articles.

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