Clinical Evaluation of 1-Hydrazinophthalazin (C-5968) in Hypertension-Reference-Cited by-同舟云学术

Clinical Evaluation of 1-Hydrazinophthalazin (C-5968) in Hypertension

Published:1952-06 Issue:6 Volume:5 Page:833-841
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

JOHNSON ROBERT L.¹,FREIS EDWARD D.¹,SCHNAPER HAROLD W.¹

Affiliation:

1. From The Cardiovascular Research Laboratory, Georgetown University Hospital; the Department of Medicine, Georgetown University School of Medicine and the Veterans Administration Hospital, Washington, D. C.

Abstract

Single oral doses of 1-hydrazinophthalazine frequently lowered blood pressure particularly diastolic pressure in hypertensive patients. Prolonged therapy was less successful, apparently as a result of development of tolerance or side effects. The best long-term results were obtained when l-hydrazinophthalazine was alternated with hexamethonium.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.5.6.833

Reference19 articles.

1. A new group of depressor substances with a special type of effect;'GROSS F.;Experientia,1950

2. Some pharmacological properties of 1-hydrazinophthalazine, a hypotensive agent;CRAVER B. N.;Federation Proc.,1950

3. The effect of 1-hydrazinophthalazine and related compounds on the cardiovascular system of dogs;'WALKER H. A.;J. Pharmacol. & Exper. Therap.,1951

4. Cardiovascular actions of 2,3-benzodiazine-4-hydrazine (C-5968);BRIITON J. B.;Federation Proc.,1951

5. Renal function and systemic blood pressure changes following the administration of hydrazinophthalazine;MOYER J. A.;J. Lab. & Clin. Med.,1950

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