Effect of timolol plus hydrochlorothiazide plus hydralazine on essential hypertension.

Author:

Aronow W S,Van Herick R,Greenfield R,Alimadadian H,Burwell D,Mann W

Abstract

The effect on hypertension of hydrochlorothiazide 100 mg daily plus timolol 20-60 mg daily versus hydrochlorothiazide plus placebo and of hydrochlorothiazide plus timolol plus hydralazine 40-200 mg daily versus hydrochlorothiazide plus placebo plus hydralazine was evaluated in a double-blind, randomized, crossover study in 38 patients with hypertension. Hydrochlorothiazide plus timolol was more effective than hydrochlorothiazide plus placebo in lowering both supine and standing systolic and diastolic blood pressures. Hydrochlorothiazide plus timolol plus hydralazine was a very effective regimen in lowering both supine and standing systolic and diastolic blood pressure. The patients tolerated this regimen well with greater hypotensive activity and a lower incidence of side effects than on hydrochlorothiazide plus placebo plus hydralazine.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Direct Vasodilators and Sympatholytic Agents;Journal of Cardiovascular Pharmacology and Therapeutics;2015-06-01

2. Hydralazine and prazosin in the treatment of hypertension.;British Journal of Clinical Pharmacology;1983-11

3. A Multiclinic Double-Blind Comparison of Timolol and Hydrochlorothiazide Alone and in Combination in the Treatment of Essential Hypertension;The Journal of Clinical Pharmacology;1983-01

4. Hypertensive Crises;Care of the Critically Ill Patient;1983

5. Biologically active 1,2,5-thiadiazoles and condensed 1,2,5-thiadiazoles (review);Pharmaceutical Chemistry Journal;1982-11

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