The Effect of "Sympatholytic Drugs on the Cardiovascular Responses to Epinephrine and Norepinephrine in Man

Author:

FREIS EDWARD D.1,MACKAY J. CALVIN1,OLIVER WILLIAM F.1

Affiliation:

1. From the Medical Service, Veterans Administration Hospital, Washington, D. C.

Abstract

Under controlled conditions the effects of various "sympatholytic" agents on the cardiovascular responses to epinephrine and norepinephrine were compared in man. The dosages of the sympatholytic drugs administered approximated those usually employed clinically. Such basic data are given for the following agents: Dibenamine, the imidazoline derivatives [Priscoline and Regitine (C-7337)], the dihydrogenated alkaloids of ergot (D.H.K. and C.C.K.), L-hydrazinophthalazine (C-5968), tetraethylammonium, and hexamethonium (C6).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference8 articles.

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2. The action of tetraethylammonium ion on the mammalian circulation;ACHESON G. H.;J. Pharmacol. and Exper. Therap.,1946

3. Effect of Pentaquine on Cardiovascular System of Unanesthetized Dogs

4. A specific sympathomimetie ergone in adrenergie nerve fibers (sympathin) and its relation to adrenaline and nor-adrenaline. Acta physiol;EULER U. S.;Scandinav.,1946

5. Evidence for the Occurrence of Nor-Epinephrine in the Adrenal Medulla

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