1. From the Second Department of Internal Medicine (T.I.), Gunma University School of Medicine, Gunma 371-8511, Japan; Center for Cardiovascular Development (Y.H.), Department of Medicine, and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Tex; and Institute for Genetic Medicine (L.K.), Department of Biochemistry and Molecular Biology, and Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles.