1. From the Cardiovascular Research Group (S.E.F.), University of Sheffield, Sheffield, UK; the Centre for Human Genetics (M.S., D.D.), University of Edinburgh, Edinburgh, UK; the Imperial Cancer Research Fund (K.H.-D.), St Thomas’ Hospital, London, UK; and the Howard Hughes Medical Institute (K.L.G., K.H.-D., B.L.B., R.O.H.), Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge.