Affiliation:
1. From the Mayo Graduate School of Medicine (University of Minnesota), Rochester: Fellow in Pediatric Cardiology (Dr. Clarkson). Mayo Clinic and Mayo Foundation: Section of Pediatrics (Drs. Weidman and DuShane), of Medicine (Drs. Frye and Burchell), and of Physiology (Dr. Wood) Dr. Wood is a Career Investigator of the American Heart Association.
Abstract
The status of 58 patients, 3 to 57 years of age, with ventricular septal defect and a marked increase in pulmonary vascular resistance (pulmonary obstructive disease) was determined 5 years or longer after diagnostic catheterization. Forty-six (80%) were alive 5 years after that study. The probability of living 5 years was 95% for patients aged 10 through 19 years and 56% for those 20 years of age or older. The dissimilarity of actuarial curves between these two groups is consistent with the hypothesis that pulmonary vascular obstructive disease develops under age 20. Calculated pulmonary resistance increased with age of patient on admission to the study, suggesting its progressive nature. Hemoptysis was rare under age 20, and its presence over this age indicated a poor prognosis. The most common causes of death were "sudden" or "unknown." Most surviving patients were gainfully employed or attending school without severe symptoms.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Cited by
70 articles.
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