White Thromboembolism in the Hamster Cheek Pouch after Trauma, Infection and Neoplasia

Abstract

White thrombosis and embolism were investigated by cinephotomicroscopy in the transillumined cheek pouch of the hamster in an experimental study of factors which may be involved in the febrile hemolytic syndrome in man, characterized by a finding of generalized platelet thrombosis of arterioles, capillaries and veins at autopsy. Endothelial trauma resulting from vascular occlusion produced platelet thrombosis and embolism. Dicumarol prevented the formation of platelet thrombosis and embolism after trauma. Heparin produced spontaneous platelet emboli and both heparin and dicumarol resulted in a leukocytic thrombosis. Platelet and leukocytic coatings and embolization were photographed during staphylococcus infection and malignant neoplasia. Sludged blood was not found in trauma, infection or malignant neoplasia.