Diminished Baroreflex Sensitivity in High Blood Pressure

Author:

BRISTOW J. DAVID1,HONOUR A. JOHN1,PICKERING GEORGE W.1,SLEIGHT PETER1,SMYTH HARLEY S.1

Affiliation:

1. From the Department of the Regius Professor of Medicine, and the Cardiac Department, Radcliffe Infirmary, Oxford, England. Work was performed during Dr. Bristow's tenure of a Special Fellowship, National Heart Institute, U. S. Public Health Service.

Abstract

Sudden intravenous injections of small amounts of angiotensin or phenylephrine were given to 30 subjects to produce modest, brief increases in directly measured systemic arterial pressure. A plot of each systolic pressure against the second succeeding cardiac cycle length produced a linear distribution, the slope of which was expressed as the millisecond increase in cycle length per mm Hg rise in systolic pressure. The slope is an index of baroreflex sensitivity and was found to have an average value of 12.8 in 18 subjects without hypertension and 2.8 in 12 others with hypertension. When all results were pooled, there was an inverse relationship between the resting mean arterial pressure and slope of the baroreflex regression lines. The findings demonstrate reduced sensitivity of the baroreflexes in hypertension, with respect to control of heart rate. A distinction is made between this change in sensitivity and simple resetting of the reflex.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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4. SMYTH H. S. SLEIGHT P. AND PICKERING G. W.: A method for the quantitative assessment of baroreceptor reflex activity in man. Submitted for publication.

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