Differential Effect of Sex on Mortality According to Age in Heart Failure

Author:

Lee Yoonpyo12ORCID,Yoon Minjae1ORCID,Choi Dong‐Ju1ORCID,Park Jin Joo1ORCID

Affiliation:

1. Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of Korea

2. School of Medicine Monash University Melbourne Australia

Abstract

Background Heart failure exhibits sex‐based differences in prevalence, clinical characteristics, and outcomes. However, these differences may have an interaction with age. This study investigates these disparities in Asian patients with acute heart failure according to age. Methods and Results We pooled data from the KorHF (Korea Heart Failure) and the KorAHF (Korean Acute Heart Failure) registries including 3200 patients between 2005 and 2009 and 5625 patients between 2011 and 2014, respectively, hospitalized for acute heart failure in Korea. Patients were categorized by their age into 2 groups: those with age ≥70 years and those with age <70 years. The primary endpoint was in‐hospital and postdischarge outcomes according to sex, stratified by age. Of 8825 patients, 45.7% had an age <70 years, and 54.3% had an age ≥70 years. Women were older on average in both groups. Differences in baseline characteristics were more apparent in the older group, with women having a higher prevalence of hypertension and valvular heart disease, whereas more men had chronic kidney disease, previous myocardial infarction, chronic obstructive pulmonary disease, and strokes. Both in‐hospital and postdischarge mortalities showed differences only in the older group, with men dying more (5.08% versus 7.41%, P <0.001; 17.95% versus 22.20%, P <0.001 respectively). This pattern persisted to adjusted analyses, which revealed that men have a 54% (odds ratio, 1.54 [95% CI, 1.17–2.04]) and 30% (hazard ratio, 1.30 [95% CI, 1.13–1.51]) increased in‐hospital and 1‐year mortality, respectively, compared with women. Conclusions In patients hospitalized with acute heart failure, male sex is an independent predictor of mortality in older patients but not younger patients.

Publisher

Ovid Technologies (Wolters Kluwer Health)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3