Cohort Study of Repeated Measurements of Serum Urate and Risk of Incident Atrial Fibrillation

Author:

Li Shanshan1,Cheng Jin2,Cui Liufu3,Gurol M. Edip4,Bhatt Deepak L.5,Fonarow Gregg C.6,Benjamin Emelia J.1,Xing Aijun2,Xia YunLong7,Wu Shouling2,Gao Xiang8

Affiliation:

1. Boston University School of Medicine Boston MA

2. Department of Cardiology Kailuan General Hospital Tangshan People's Republic of China

3. Department of Rheumatology and Immunology Kailuan General Hospital Tangshan People's Republic of China

4. Massachusetts General Hospital Harvard Medical School Boston MA

5. Brigham and Women's Hospital Harvard Medical School Boston MA

6. David Geffen School of Medicine University of California Los Angeles CA

7. Department of Cardiology First Affiliated Hospital of Dalian Medical University Dailian People's Republic of China

8. Department of Nutritional Sciences Pennsylvania State University State College PA

Abstract

Background Current evidence on the association between serum urate and risk of atrial fibrillation ( AF ) is limited by cross‐sectional designs and 1‐time measurement of serum urate. The roles of serum urate, gout‐related inflammation, and systemic inflammation in the etiology of AF are currently unknown. This gap is important, given that systemic inflammation is a recognized risk factor for AF . Methods and Results We conducted a prospective cohort study of 123 238 Chinese patients from 2006 to 2014. Serum urate concentrations were measured in 2006, 2008, 2010, and 2012. Incident AF cases were identified via biennial 12‐lead ECG assessment. We used a Cox proportional hazards model to examine the sex‐specific associations of cumulative average serum urate and changes in serum urate accounting for baseline level with risk of incident AF . We also assessed the joint associations of serum urate and high‐sensitivity C‐reactive protein levels. Comparing extreme categories, participants with the highest quintile of serum urate had 1.91‐fold higher risk of AF (adjusted hazard ratio: 1.91; 95% CI, 1.32–2.76; P =0.001 for trend). Participants with both high serum urate and high‐sensitivity C‐reactive protein had 2.6‐fold elevated risk of incident AF compared with those with normal levels of serum urate and high‐sensitivity C‐reactive protein (adjusted hazard ratio: 2.63; 95% CI, 1.63–4.23). Conclusions High serum urate levels and increases in serum urate over time were associated with increased risk of incident AF . Patients with high levels of both serum urate and high‐sensitivity C‐reactive protein had substantially higher risk of AF .

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Cited by 36 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3