Affiliation:
1. Department of Cardiology Tokyo Women's Medical University Tokyo Japan
Abstract
Background
The association between first‐degree atrioventricular block (
AVB
) and life‐threatening cardiac events in patients with hypertrophic cardiomyopathy (
HCM
) remains unclear. This study sought to investigate whether presence of first‐degree
AVB
was associated with
HCM
‐related death in patients with
HCM
.
Methods and Results
We included 414 patients with
HCM
(mean age, 51±16 years; 64.5% men). The P‐R interval was measured at the time of the initial evaluation and patients were classified into those with and without first‐degree
AVB
, which was defined as a P‐R interval ≥200 ms.
HCM
‐related death was defined as a combined end point of sudden death or potentially lethal arrhythmic events, heart failure–related death, and stroke‐related death. First‐degree
AVB
was noted in 96 patients (23.2%) at time of enrollment. Over a median (interquartile range) follow‐up period of 8.8 (4.9–12.9) years, a total of 56 patients (13.5%) experienced
HCM
‐related deaths, including 47 (11.4%) with a combined end point of sudden death or potentially lethal arrhythmic events. In a multivariable analysis that included first‐degree
AVB
and risk factors for life‐threatening events, first‐degree
AVB
was independently associated with an
HCM
‐related death (adjusted hazard ratio, 2.41; 95%
CI
, 1.27–4.58;
P
=0.007), and this trend also persisted for the combined end point of sudden death or potentially lethal arrhythmic events (adjusted hazard ratio, 2.60; 95%
CI
, 1.28–5.27;
P
=0.008).
Conclusions
In this cohort of patients with
HCM
, first‐degree
AVB
may be associated with
HCM
‐related death, including the combined end point of sudden death or potentially lethal arrhythmic events.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
10 articles.
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