Author:
Choki J I,Yamaguchi T,Takeya Y,Morotomi Y,Omae T
Abstract
Regional cerebral blood flow (rCBF) was measured in normotensive rate (NTR) and spontaneously hypertensive rats (SHR), in a lightly anesthetized state and with control of PaCO2 by artificial ventilation. Without carotid artery ligation, NTR and SHR showed almost identical rCBF values and distribution, despite significantly elevated levels of blood pressure in SHR. Bilateral carotid artery ligation, however, caused much more pronounced decreases of rCBF (ischemia) in SHR than NTR, in regions supplied by the carotid artery. The reduction of rCBF in SHR was rather homogenous and symmetrical. Mechanisms causing the differences between NTR and SHR are discussed.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology
Reference17 articles.
1. Upper limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon.
2. Yamaguchi T Choki J Morotomi Y etal: Response of pial arteries to papaverine hydrochloride after carotid ligation in normotensive and spontaneously hypertensive rats (in Japanese with English abstract) J Jap Coll Angiol 16: 215-221 1976
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