1. From the Department of Molecular Cardiovascular Biology and Pharmacology (L.-J.M., M.M., F.J., K.T., K.O., J.I., M.H.), Ehime University Graduate School of Medicine, Tohon, Ehime, Japan; Division of Medical Bioscience (M.S.), Department of Bioscience, Integrated Center for Sciences, Ehime University, Tohon, Ehime, Japan.