1. From the Department of Physiology, Bristol Heart Institute, School of Medical Sciences (H.W., B.L., S.K., J.F.R.P.), and Henry Wellcome Laboratories for Integrated Neuroscience and Endocrinology (D.M.), University of Bristol, Bristol, United Kingdom; and the Department of Physiology (M.M.) and Experimental Animal Center (K.K.), Fukushima Medical University School of Medicine, Fukushima, Japan