Nitric Oxide Production and Endothelium-Dependent Vasorelaxation Ameliorated by N 1 -Methylnicotinamide in Human Blood Vessels

Author:

Domagala Teresa B.1,Szeffler Agata1,Dobrucki Lawrence W.1,Dropinski Jerzy1,Polanski Stanisław1,Leszczynska-Wiloch Magdalena1,Kotula-Horowitz Katarzyna1,Wojciechowski Jacek1,Wojnowski Leszek1,Szczeklik Andrzej1,Kalinowski Leszek1

Affiliation:

1. From the Departments of Medical Biochemistry (T.B.D.) and Medicine (T.B.D., J.D., S.P., K.K.H., A.S.), Jagiellonian University Medical School, Krakow, Poland; Departments of Medical Laboratory Diagnostics (A.S., M.L.W., L.K.) and Cardiovascular Surgery (J.W.), Medical University of Gdansk, Gdansk, Poland; Division of Cardiovascular Medicine (L.W.D.), Department of Internal Medicine, Yale University School of Medicine, New Haven, CT; Beckman Institute for Advanced Science and Technology (L.W.D.),...

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

Reference16 articles.

1. Enzymology of NAD+ homeostasis in man

2. 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin;Gebicki J;Pol J Pharmacol,2003

3. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway

4. 1-Methylnicotinamide (MNA+) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats;Bartus M;Pharmacol Rep,2008

5. Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin

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