1. From the Robarts Clinical Trials (R.D.F., G.Y.Z., M.K.V., C.J.W., S.A.E.N., B.G.F.), Robarts Research Institute, London, Ontario, Canada; Schulich School of Medicine and Dentistry, Department of Medicine (R.D.F., B.G.F.), Department of Physiology and Pharmacology (R.D.F.), and Department of Epidemiology and Biostatistics (G.Y.Z., B.G.F.), University of Western Ontario, London, Ontario, Canada.