1. From the Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (A.A., L.V.G., U.K., M.M., G.G.S., S.Y.P., C.M.S., D.K.); Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer, Israel (D.K.); and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (D.K.).