1. From the Clinical Pharmacology Unit, University of Cambridge, Centre for Clinical Investigation, Addenbrooke’s Hospital, Cambridge, UK (A.L.B., J.J.M., P.Y., J.C., I.B.W., A.P.D.); Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK (A.D., M.S.); and Unilever Centre for Molecular Sciences Informatics, Department of Chemistry, University of. Cambridge, Cambridge, UK (R.T., R.C.G.).