1. From the Department of Obstetrics and Gynecology (H.S., A.O., S.M., Y.T., M.Su.), Jichi Medical University School of Medicine, Tochigi, Japan; Division of Genetics (M.M., M.Sh.), Institute of Medical Science, University of Tokyo, Tokyo, Japan; Institute of Development, Aging, and Cancer (Y.S.), Department of Vascular Biology, University of Tohoku, Sendai, Japan.