1. From the Heart Institute (InCor) (T.V.P., A.C.P., J.E.K.) and Clinical and Toxicological Analysis Department (M.R.), Faculty of Pharmaceutical Sciences, University of Sao Paulo Medical School, São Paulo, Brazil; Division of Nephrology (A.C.F.N.), São Paulo University Medical School, University of São Paulo, São Paulo, Brazil; and the Department of Human Functional Genomics (Y.Y.), Life Science Research Center, Mie University, Mie, Japan.