1. From the Cardiovascular Research Group (A.S.G., A. Price, K.S., A. Paisley, K.K., S.W., L.S., R.A.M., A.M.H.), Department of Medicine, Manchester University, Manchester, United Kingdom; Wellcome Trust Clinical Research Facility (A.S.G., A.M.H.), Manchester Royal Infirmary, Manchester, United Kingdom; and the University of Texas Medical Branch/Methodist Hospital of Houston (O.P.), Tex.